2-(2-Amino-5-bromobenzoyl)pyridine (CAS 1563-56-0): A Technical Procurement and Specification Guide

For technical purchasing teams, formulation chemists, and quality professionals evaluating specialty intermediates, few identifiers carry as much weight as the CAS registry number. It is the single string that travels through quotations, regulatory filings, safety documents, and customs paperwork — and when it is wrong, everything downstream breaks. In the case of 2-(2-Amino-5-bromobenzoyl)pyridine, that identifier is CAS 1563-56-0. Supplied by Hubei Reaction Technology Co., Ltd. (Reaction), this compound sits within our portfolio under Section C — Other Intermediates & Rubber Additives, where it serves as a specialized building block for further chemical synthesis rather than as a finished commodity product.

This guide expands on what the product is, why its CAS number matters so much in practice, and how procurement and technical teams should approach qualification, specification, and supply-chain verification when sourcing it for research, scale-up, or ongoing production.

1. The Identifier That Anchors Everything: CAS 1563-56-0

The CAS (Chemical Abstracts Service) registry number is a globally recognized, unique numerical identifier assigned to a specific chemical substance. For 2-(2-Amino-5-bromobenzoyl)pyridine, that number is 1563-56-0. Its value is not cosmetic — it is operational.

For procurement, the CAS number is the shortest possible way to guarantee that two parties are discussing the same molecule. A trade name can vary by supplier; a molecular formula can be shared by isomers; a casual description ("the bromo amino pyridine benzoyl thing") is useless across languages. The CAS number removes ambiguity. When a buyer references CAS 1563-56-0 in an inquiry, the technical and sales teams can respond with an accurate quotation instead of a clarification loop.

For regulatory documentation, the CAS number is the key that unlocks hazard communication. Safety Data Sheets, import licenses, and restricted-substance screenings are all indexed by CAS. A correct CAS means the right GHS classification, the right transport category, and the right labeling regime are applied from the first shipment.

For supply-chain verification, the CAS number lets downstream customers and auditors confirm that the material they received matches what was ordered, what was declared, and what was tested. In a multi-tier supply chain, that traceability is what turns a "trust me" relationship into a documented one.

In short, CAS 1563-56-0 is the reliable starting point for qualification. Everything else — assay, packaging, documentation, delivery — is built on top of it.

2. Chemical Structure and Why It Matters

Understanding the name 2-(2-Amino-5-bromobenzoyl)pyridine tells you almost everything about the molecule's potential. Structurally, it combines an amino-substituted bromobenzoyl aromatic system with a pyridine ring, linked through a carbonyl (benzoyl) bridge.

Breaking that down:

• The pyridine ring is a six-membered heteroaromatic ring containing one nitrogen atom. The nitrogen introduces a site for coordination and a point of differing electronics versus a plain phenyl ring, which is often useful when the molecule is later built into more complex structures or used as a ligand-like scaffold.
• The benzoyl group (a benzene ring attached through a carbonyl) acts as the bridge linking the pyridine to the substituted benzene portion. The carbonyl is itself a versatile functional handle.
• The bromine atom at the 5-position of the benzoyl ring is a halogen substituent. Bromine is a particularly useful leaving group and coupling partner — it readily participates in cross-coupling reactions that stitch the fragment into larger molecules.
• The amino group at the 2-position is a nucleophilic, basic functionality. Amino groups are classic sites for further cyclization, acylation, or salt formation downstream.

The combination — a brominated, amino-substituted benzoyl fragment wired to a pyridine — is precisely why this intermediate is of interest in the development of advanced organic intermediates and performance-related formulations. Each moiety contributes a distinct reactivity, and together they give synthetic chemists multiple "handles" to modify the molecule without redesigning it from scratch.

3. Where It Lives in Reaction's Portfolio

Reaction organizes its catalog into clear sections so that customers can navigate the offering efficiently. This product is listed under Section C — Other Intermediates & Rubber Additives. That placement is deliberate: it reflects the compound's role as a specialized building block rather than a high-volume bulk chemical.

Within a portfolio that also spans the benzophenone series, additional fine-chemical intermediates, and rubber additives, Section C captures the "connective tissue" molecules — the more tailored intermediates that support custom synthesis, research programs, and niche formulation work. For a buyer, the section label is itself a signal: this is a product best approached through technical discussion, not a one-click commodity purchase.

4. Role as a Synthetic Building Block

As an intermediate, 2-(2-Amino-5-bromobenzoyl)pyridine is valued less for what it is on its own and more for what it can become. The structural features described above — bromo, amino, pyridyl, and carbonyl motifs in one compact framework — enable a wide range of downstream transformations:

• The bromine can be engaged in palladium-catalyzed cross-couplings to attach new aromatic or heteroaromatic groups.
• The amino group can be condensed, acylated, or cyclized to form ring systems.
• The pyridine nitrogen can coordinate metals or participate in further heterocycle construction.
• The carbonyl offers a site for reduction or nucleophilic addition.

Compounds that pair a pyridine ring with a substituted benzoyl fragment are frequently encountered in pharmaceutical and agrochemical research, as well as in the synthesis of ligands and functional materials. We describe this product as being "of interest in the development of advanced organic intermediates and performance-related formulations" precisely because its value is realized through these downstream steps, not as a final product in itself.

5. Key Commercial Specifications Buyers Should Define

The CAS number gets you to the right molecule. The commercial specification is what tells you whether a given batch is fit for your purpose. For 2-(2-Amino-5-bromobenzoyl)pyridine, the following parameters are normally confirmed according to project requirements, order volume, and applicable quality standards:

• Assay / purity level. The minimum purity (often verified by HPLC or GC) defines whether the material meets the needs of a research lab versus a validated production route. Higher assay typically means tighter impurity control.
• Appearance. A defined color and physical form (powder, crystalline solid, etc.) is a quick incoming-inspection checkpoint before any analytical testing.
• Packaging size. The container and quantity — from gram-scale research packs to larger production drums — are matched to order volume and handling constraints.
• Documentation. A Certificate of Analysis (CoA) and Safety Data Sheet (SDS) are the baseline; additional certificates may be required by the destination market or industry.
• Delivery conditions. Incoterms, lead time, and shipping mode are aligned with the buyer's logistics plan.

The important point is that these are not fixed, one-size-fits-all numbers. They are confirmed through dialogue between the buyer's technical team and Reaction's specialists, balanced against the project's stage (research vs. scale-up vs. routine production) and the relevant quality benchmark.

6. Documentation and Quality Assurance

For any serious intermediate, the document package matters as much as the molecule. Reaction supports customers by ensuring that product supply is aligned with technical discussions, quality expectations, and logistics needs.

A typical documentation set includes:

• A CoA that reports the tested assay and key impurity and physical parameters for the specific batch.
• An SDS that communicates hazard classification, handling, and emergency measures under the applicable GHS transposition (such as EU CLP, US OSHA HCS, or China GB 30000).
• Supporting records that demonstrate batch-to-batch consistency and traceability through the manufacturing process.